Cell response to substrate topography

M. Reza Ejtehadi
Sharif University of Technology Tehran, Iran

Abstract:
Cells sense and respond to changes in topographical, chemical, and mechanical characteristics of their substrate. Engineered substrates are increasingly being developed that exploit these physical attributes to direct cell responses and therefore control cell behavior toward desired applications. However, there are very few methods available for robust and accurate modeling that can predict cell behavior prior to experimental evaluations, and this typically means that many cell test iterations are needed to identify best material features. Here, we developed a computational framework to predict cell behavior prior to experimental evaluations. The model which we call it “virtual cell model” has the capability to predict changes in whole cell and cell nucleus characteristics on a range of cell substrates.